A third of patients discontinued the drug in that highest dose group, though a group that titrated slower and also to a lower dose had much higher completion rates, only a fifth discontinued
[DOI] [PMC free article] [PubMed] [Google Scholar] 35.ONeil PM, Birkenfeld AL, McGowan B, Mosenzon O, Pedersen SD, Wharton S, et al
The injectable versus oral peptide comparison is also relevant here, because some researchers transitioning from oral semaglutide may have different GLP-1 receptor adaptation profiles than those coming from injectable formulations
A 2020 review by the Journal of the International Society of Sports Nutrition (JISSN) summarized over 70 studies and found that L-carnitine supplementation: Improves muscle oxygenation during exercise Reduces exercise-induced muscle damage Enhances recovery rates after intense workouts Provides mixed results for direct weight loss, although it consistently supports fat metabolism These findings help answer the question does L-carnitine work, especially when your goal is improving performance and recovery rather than relying on it as a standalone fat-loss supplement
