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This interval allows: GI side effects (nausea, vomiting, diarrhea) from the current dose level to subside The body to adapt to the rate of gastric emptying at that dose Clinicians to assess tolerability before increasing further Time to reach maximum dose week 20 (after five four-week steps: 1mg, 2mg, 4mg, 8mg, 12mg)

[18] Eligibility criteria, treatment duration, and monitoring requirements are defined within this appraisal and associated specialist service frameworks

When treatment stops, many people notice their appetite and hunger returning to pre-medication levels over the first week or so

Visceral fat, which wraps around organs and increases metabolic risk, dropped more in the treatment group compared to placebo