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The Phase 2 trial enrolled participants with obesity and evaluated multiple dose levels over 48 weeks: 1 mg dose: 8.7% average body weight reduction 4 mg dose (escalated from 2 mg): 17.1% average body weight reduction 8 mg dose (escalated from 2 mg): 22.8% average body weight reduction 12 mg dose (escalated from 2 mg): 24.2% average body weight reduction Placebo: 2.1% average body weight reduction Those Phase 2 numbers were striking enough

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These guidelines for missed doses are designed to prevent you from having too much semaglutide in your system, which can increase your risk of side effects

They are not inevitable or irreversible, but they do warrant attention rather than being treated as an acceptable side effect to push through