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The immune system reacts to the infection, but over time it can accidentally begin attacking the stomach as well

[41] Amphetamine also induces contraction in the urinary bladder sphincter, the muscle which controls urination, which can result in difficulty urinating

The simultaneous activation of NF-B and Nrf2 creates antagonistic interactions where p65, a subunit of NF-B, suppresses Nrf2 activity to drive the expression of ARE genes, such as HO-1, without p65s own transcriptional activity