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The European Food Safety Authority (EFSA) has set an adequate intake (AI) of 4.0 g/day for adults (EFSA, 2015)

The methionine, inositol, and choline are lipotropic agents, compounds that support fat metabolism in the liver, while B12 supports energy metabolism and methylation

Inflammation calms down

DNA testing required for formal diagnosis (not a first-line investigation, exclude other causes first) Pre-pregnancy carrier testing of partner is important Rare causes of microcytic anaemia Chronic inflammation Lead poisoning (high blood lead level) Sideroblastic anaemia Normocytic normochromic anaemia Haemolytic anaemia Acute haemolysis in childhood can be a life-threatening illness and all cases should be discussed with a haematologist Admit children with haemolytic anaemia for observation