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they did not increase the risk of withdrawal or adverse events compared with the control.58 Hyaluronic acid Glucosamine A two-year placebo-controlled study into glucosamine for osteoarthritis found that adverse reactions were not meaningfully different among treatment groups and serious adverse events were rare for all therapies.61 And a large review of similar studies also found that glucosamine was as safe as a placebo.62 Of course, there are groups for whom some of these ingredients would be a poor choice, and there are also less common ingredients in many anti-aging complexes that deserve some safety attention, as well

PLoS ONE 3 , e1797 (2008)

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