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Targeting B cell differentiation limits their functionality with medications like belimumab and atacicept, but comes at the expense of reducing some cell signals and possible pneumonia

KPV's anti-inflammatory contribution is relevant here: synovial inflammation is a consistent feature of chronic joint stress models, and the reduction of IL-1 and TNF- that KPV demonstrates in cell culture models would be a logical correlate in a joint-stress research context [7]