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However, a recent wave of studies has painted a more nuanced picture, suggesting that the story might be far from the ideal narrative we've hoped for

Studies in Crat knockout mice demonstrated that CrAT deficiency leads to abnormal fuel selection, which results in a perturbation of glucose homeostasis and suggest that deficits in CrAT activity might contribute to diet-induced metabolic inflexibility by exacerbating the Randle glucose-fatty acid cycle 66

AOD 9604/MOTS-c is given as a subcutaneous injection on a provider-determined schedule

At defined time points (0, 30, 60, and 90 s), 40 L samples were heat inactivated and the aldehyde concentration was determined as detailed above