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Under normal physiological conditions, microglia and astrocytes protect neurons by eliminating pathogens and cellular debris, as well as releasing neurotrophic factors, thereby maintaining homeostasis
For example, ER stress can promote acinar cell apoptosis by activating the p53/AIFM2 axis and the PERKJNK pathway, 252,253,254,264 induce caspase-1-dependent pyroptosis via activation of the PERK pathway, 265 and trigger necroptosis in pancreatic acinar cells by enhancing CTSB maturation and activating the PKCJNKc-Jun cascade
Whether the same rebound would occur with addiction, and what it would mean for someone in recovery to face the roar of craving again, is unknown
Aug 2017;471:248-253
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