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The Biochemical Journal, 129 (1), 5565

Gastrointestinal Side Effects That May Affect Running Semaglutide commonly causes gastrointestinal (GI) side effects, including nausea, vomiting, bloating, constipation, and diarrhea

"Most people taking GLP-1 medications will never develop a bezoar," Dr Kuchay reassured

It seems that weight loss will likely be very important for the benefits of the GLP-1 medicines in some conditions, and much less important, or not at all essential, for benefits in other disorders. According to Lane, although GLP-1 receptor agonists show promise in reducing cardiovascular risk factors, long-term cardiovascular safety trials are needed to assess cardiovascular mortality and events