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But these factors may play roles: Gene changes

Clinical pharmacology of incretin therapies for type 2 diabetes mellitus: implications for treatment

In contrast, limited weight loss or persistent appetite should prompt assessment of medication exposure, dose escalation, gastrointestinal tolerability, adherence, treatment interruption, concomitant medications, dietary compensation, and behavioural drivers of eating, consistent with evidence that early response may help identify patients more likely to achieve clinically meaningful longer-term weight loss (93)