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Longitudinal data have shown that substantial weight loss is independently associated with shifts in relationship dynamics, including increased rates of separation, which means informed consent for GLP-1 therapy should incorporate discussion of anticipated psychosocial changes alongside the more commonly addressed physical side effects

While SGLT2 inhibitors remain the cornerstone for reducing HF hospitalizations, semaglutide offers complementary benefits.(9) Future research should evaluate combination therapy of SGLT2 inhibitors with GLP-1 RAs, compare GLP-1 agonism to other HFpEF therapies, and provide long-term mortality data

Be Patient and Consistent Managing constipation on GLP-1 medication may take some time and experimentation

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