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Gout is not listed as a recognised adverse effect in the Summary of Product Characteristics (SmPC) for semaglutide, and the drug's mechanism of action does not directly influence uric acid metabolism or crystal formation in joints
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Immunohistochemistry revealed positive staining for ACTA2, a myofibroblast marker, in the xenograft lesions from both cell lines, and the proportion of ACTA2-positive cells did not differ significantly between HOXC8-imESCs (62.5% 2.8%) and Control-imESCs (65.1% 1.2%) ( p = 0.398) (Figs
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A 1.7-fold increase in physiological L-carnitine levels was previously reported in a mouse model of NASH 15
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