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Second, it launched a citrate-free high-concentration formulation of Humira that could not be automatically substituted because the citrate-free biosimilars had not yet achieved interchangeability designation for that specific formulation

Stability is the real limit: reconstituted retatrutide holds 46 weeks refrigerated, so match the vial to the weekly draw rate so it is used up inside that window

A person taking 0.25 mg once weekly who accidentally doses 0.5 mg is still well below the FDA-approved maximum