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This finding may be due to the fact that the prevalent mutation in Sardinia (Mediterranean variant, S188F) is more severe (Class II) than the one affecting African-Americans (G6PD A, 202A/376G) (Class III) and is characterized by a significantly lower residual activity [17]

macrocephala and Alisma orientale ), attenuates mesangial hypertrophy and basement-membrane thickening by inhibiting the TGF-/Smad and p38 MAPK signalling pathways (Wang et al., 2025)