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While caffeine has been shown to increase sex hormone binding globulin (SHBG), which can slightly lower the levels of free testosterone, these effects are not substantial enough at normal caffeine consumption levels to raise concerns 1

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Drmic et al., 2017), neurotoxin cuprizone-induced multiple sclerosis in a rat model (Klicek et al., 2013), and magnesium overdose (Medvidovic-Grubisic et al., 2017))