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In a prospective real-world cohort of 194 adults with type 2 diabetes initiating semaglutide or dulaglutide, only 49% achieved 5% weight loss by 12 months meaning that just under half of treated patients did not meet the threshold conventionally defined as clinically meaningful (Vozza et al., 2025)

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Now that GLP-1 agonists are a prominent treatment for overweight and obesity, researchers have begun looking at how patients with rheumatologic diseases respond to these products