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In all family members, the first transcript variant corresponds to the canonical variant

If the liver is exposed to an excess of APAP, however, these detoxification processes are overwhelmed, and APAP is instead metabolized by the cytochrome P450 enzyme CYP2E1 into the highly reactive and toxic metabolite NAPQI 4

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AIDS 11:1926 Moretti S, Alesse E, Di Marzio L, Zazzeroni F, Ruggeri B, Marcellini S, Famularo G, Steinberg SM, Boschini A, Cifone MG, De Simone C (1998) Effect of l-carnitine on human immunodeficiency virus-1 infection-associated apoptosis: a pilot study