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In addition to weight gain, postmenopausal women may experience hot flashes, intense mood swings, dizziness, changes in insulin sensitivity, brain fog, and other menopausal symptoms as well

The absence of Nlgn4 weakens glutamatergic and GABAergic synaptic transmission, tilting the excitation/inhibition balance toward inhibition (89)

Pretreatment with each examined GLP-1 analogs, including GLP-1(736), liraglutide, and exendin-4, led to significantly reduced Ca 2+ responses (by 53.8%, 58.1%, and 72.2%, respectively)

Orforglipron also showed clinically meaningful improvements from baseline across key cardiovascular risk factors