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gentle swirling is sufficient if mixing is required Minimise the number of times the vial is accessed, as repeated needle punctures increase contamination risk Label the vial clearly with the date and time of reconstitution, and with the sponsor-validated beyond-use date Follow all additional handling instructions specified in the IMP label or protocol These measures help to slow the degradation processes described above

doi:10.1111/jfbc.13801

Additionally, these medications have been shown to protect kidney function

Table 1: Medicines reported to be associated with gynaecomastia [this is not an exhaustive list] 2-7 *Classification of quality of evidence for strength of medicine associations with gynaecomastia