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The cold temperature significantly slows down the molecular motion and enzymatic activity that would otherwise tear the peptide apart

The name originates from fitness and recovery communities referencing the Marvel character's regenerative abilities, and the combination has been widely discussed across biohacking circles and podcasts like the Joe Rogan Experience

IGF-1 has been proved to promote the biomineralization on the surface of chitosan nanoparticles [72], and the use of porous chitosan scaffolds to adsorb IGF-1 can effectively promote the healing of bone defects [73]