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As kidney function deteriorates, these toxins accumulate in the blood, causing many deleterious effects on body tissues and organs, thereby contributing to kidney damage and related complications such as cardiovascular disease and neurological disorders (Krukowski et al., 2023

Inflammatory processes contribute to all phases of the life cycle of atherosclerotic plaques, from initiation to the ultimate thrombotic complications [8]

The snx1/snx2a/snx2b triple mutant shows slightly more pronounced defects in overall growth but displays negligible phenotypic changes during embryonic development (Fig

10.1016/j.ccm.2013.09.005 16 CheW.Lerner-MarmaroshN.HuangQ.OsawaM.OhtaS.YoshizumiM.et al (2002)