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Hence, the pathophysiological role of LPL activity in NAFLD remains elusive ( Figure 4 )

J Biol Chem 1950, 187: 697-703

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By contrast, preclinical in vivo and in vitro studies both indicate that incretin receptor agonism can attenuate fibrogenic signalling in models of kidney disorders, and thus the positive clinical trial data on kidney function outcome measures may, in part, be mediated by inhibition of fibrosis