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Sensitivity Analyses A probabilistic sensitivity analysis (PSA) was performed using a second-order Monte Carlo approach, with sampling around the base case clinical inputs based on the standard errors of the proportions of patients achieving targets collected in the PIONEER 2, 3, and 4 trials (Table 1)

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Properdistatin, a new peptide generated from the plasma protein properdin, inhibited angiogenesis in A-07 human melanoma xenografts, according to Wu et al