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Three small human pilot studies have now been published: a 2021 pilot of 16 knee pain patients reported 87.5% pain relief at 612 months [PMID: 34324435]

Therefore, targeting the HIF1-c-MYC-PGC1 pathway enhances thermogenesis in beige adipose tissue, thereby providing a potential therapeutic strategy to mitigate obesity and metabolic disorders associated with high-fat diets [142]