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Carrasco D, Lefevre T, Moiroux N, Pennetier C, Chandre F, Cohuet A

Enriched PBMCHSPC suspensions were subjected to multimodal single-cell profiling using combined single-nuclei RNA-sequencing and ATAC-sequencing (snRNA/ATAC-seq) ( Autopsy datasets and ICU cohorts Autopsy datasets reflect end-state disease following severe acute SARS-CoV-2 infection and were included to characterize the maximal extent of tissue-level immunometabolic perturbation, rather than to model post-acute sequelae of COVID-19

The fundamental distinction in subcutaneous vs intramuscular peptide injection lies in the tissue depth reached and the vascular density of that tissue

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