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Our findings broadly support the recommendation against use of these medications in both pregnancy and during lactation, in particular given effective and safe alternatives are available

The tissue extracts were diluted as necessary with acetonitrile/DI water to fit the calibration range

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Therefore, advancing from non-specific epigenetic modifiers to isoform-selective inhibitors or locally delivered agents represents a promising translational path to harness the potential benefits of HDAC modulation for tinnitus treatment while mitigating the risks associated with systemic, broad-action compounds