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NICE guidance emphasises that metabolic abnormalities should be investigated thoroughly before treatment
As tirzepatide clears over 3-4 weeks, gastrointestinal symptoms typically improve gradually, appetite may return, and blood glucose levels may rise in patients with diabetes
Subjects who withdrew from the randomized withdrawal period and who did not provide efficacy data at their last on-treatment visit were classified as treatment failures (Study 6, Figure 5)
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