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Their exceptional chemical stability allows environmental persistence exceeding two decades, leading to progressive bioaccumulation through food webs and preferential storage in lipid-rich tissues ( Human exposure to these compounds occurs through multiple pathwaysingestion, inhalation, and dermal absorptionwith subsequent accumulation in adipose tissue, hepatic systems, and critically, reproductive organs ( 1.2 Key research challenges Despite substantial advances in understanding individual EED toxicity profiles, several fundamental knowledge gaps continue to impede comprehensive risk assessment: Complex Mixture Effects Remain Poorly Understood While toxicological studies have extensively characterized individual EED effects, real-world human exposure invariably involves simultaneous contact with multiple compounds

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GAB1 is associated with c-MET receptor via 13 amino acid MET binding sites and indirectly through MET-bound GRB2 [35]

D.et al (2009)