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Semaglutide weight loss by dose 0.25 mg : Starter dose, so minimal weight loss 0.5-1 mg: Moderate weight loss of about 5-7% at 3-6 months, and up to 7% at 28-68 weeks 1.7 mg: 10-12% weight loss at 28-68 weeks 2.4 mg: 15% average weight loss at 68-104 weeks What if the side effects are too strong