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Dedicated, prospective studies with adequate sample sizes, long-term follow-up, and comprehensive metabolic phenotyping are urgently required to validate these preliminary observations and establish evidence-based, genotype-specific treatment approaches

Results of two randomized placebo-controlled trials of liraglutide in patients with advanced systolic heart failure, with or without diabetes, failed to demonstrate benefit of liraglutide, and the trend in both trials was worse outcomes with liraglutide versus placebo

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