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While specific guidelines on continuing therapy after HbA1c normalization are lacking, current evidence supports ongoing use of these agents due to their insulin-independent mechanisms of action

Why Tirzepatide Causes Nausea in the First Days Tirzepatide nausea stems from its mechanism: it slows gastric emptying (how fast your stomach moves food into your small intestine) and triggers satiety signals in your brain through GLP-1 and GIP receptor activation

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But tirzepatide, despite causing significant fat loss , did not make this slowdown worse compared to placebo after adjusting for body weight and composition changes