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Some patients experience mild fatigue during the first two weeks

The purposes of this study are: -To find the highest dose of melphalan that can be given with BSO without causing severe side effects

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The most common adverse events included nausea, affecting 38.1% to 43.2% of treated patients compared to 10.7% with placebo, diarrhea in 33.1% to 34.7% versus 13.4% with placebo, and constipation in 21.8% to 25% compared to 8.7% with placebo