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LHCGR engagement activates Gs-coupled adenylyl cyclase, driving cAMP accumulation and PKA-mediated phosphorylation of downstream steroidogenic targets including CYP11A1, CYP17A1, and 3-HSD

Waiting until significant loose skin has already developed makes the problem harder to address

Why mechanism alone keeps failing this test The history of dermatology and pharmacology is full of compounds with impeccable mechanistic rationales that did not translate into clinical benefit, or that worked by one route and not another

Accumulation of nitrotyrosine on the SERCA2a isoform of SR Ca-ATPase of rat skeletal muscle during aging: a peroxynitrite-mediated process