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408 In line with this hypothesis, the loss of NAPRT in both RCC cell lines and EMT-subtype gastric cell lines renders the cells hypersensitive to NAMPT inhibitors, such as FK866, and KPT-9274, suggesting that NAMPT inhibitors may be a promising strategy for NAPRT deficient tumors

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They are distributed worldwide, and have been isolated from soil, air, sewage, seawater, chlorinated swimming pools, domestic tap water, bottled water, dental treatment units, hospitals, air-conditioning units, and contact lens cases

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