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There are no approved therapies for youth that have demonstrated a clinically meaningful impact on body weight or BMI reduction compared with placebo. Hannon said the 2025 American Diabetes Association Standards of Care currently recommend GLP-1 therapy if children and adolescents with type 2 diabetes are unable to achieve an HbA1c of 6.5% or less with metformin or insulin therapy

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Titration, Monitoring & Protocol Adjustment Both semaglutide and tirzepatide require slow titration to minimize GI side effects and allow your body to adapt