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A standard-dose semaglutide or tirzepatide protocol may be a better fit if your primary goal is significant weight loss, you have a higher starting BMI, you struggle with strong appetite or food noise, you want more noticeable appetite suppression, or you have previously tolerated GLP-1 medications well

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Studies show that this type of diet actually alters the circadian rhythm of GLP-1 secretion, both in lab animals and in people with type 2 diabetes.[ref] Does a decrease in natural GLP-1 secretion explain the obesity epidemic