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Importantly, in these and other clinical trials, the safety profile of GLP-1 receptor agonists was well established

Scars & Recovery: The incision is made low along the bikini line so the scar can be easily concealed under underwear or swimwear

RNA isolation and qRTPCR analysis Total RNA was extracted using TRIzol (Takara Bio, Tokyo, Japan) and quantitative reverse transcription polymerase chain reaction (qRTPCR) was performed using Hieff qPCR SYBR Green Master Mix (Vazyme, Nanjing, China) according to the manufacturers instructions

LY3463251 is the first GDF-15 receptor agonist to complete a Phase I clinical trial, with results showing an average weight reduction of 3% in patients after 12 weeks of treatment