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Moreover, the observation that adding GLP-1MK-801 treatment on top of semaglutide leads to an additional weight loss of 7% in mice that have reached a weight loss plateau with semaglutide provides additional support for integrating NMDA receptor antagonism in next-generation weight loss therapeutics

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Retatrutide: 28.7% in TRIUMPH-4 In Lillys Phase 3 TRIUMPH-4 trial, participants taking retatrutide 12 mg lost an average of 28.7% of body weight at 68 weeks using the efficacy estimand