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A positive reaction, indicated by redness, swelling, or blistering at the test site, confirms the allergy

These features enable COFs to serve not only as efficient drug delivery carriers but also as multifunctional platforms capable of synergistically enhancing various therapeutic modalities-such as PDT, PTT, chemodynamic therapy (CDT), SDT-through responsiveness to the tumor microenvironment (e.g., hypoxia, H 2 O 2 , GSH)

These findings suggest that AtGLRs coordinate phytohormone signalling and Ca 2+ homeostasis to fine-tune cold adaptation responses

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