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Finerenone is also being investigated in a phase 3 placebo-controlled study in non-diabetic CKD (FIND-CKD) (Table 3)

Additional populations requiring careful consideration include patients with kidney disease (specific recommendations vary by medication), those with a history of diabetic retinopathy (particularly if rapidly improving glycemic control), and individuals with active or recent malignancy

DON, when included, was also present during the final 10 min of the pre-incubation

The primary safety concern is not a direct drug interaction but rather a practical one: ondansetron may prevent you from recognizing early signs that your dose is too high or escalating too quickly