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Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase to Regulate Proteasomal Degradation of Nrf2

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Interplay between GLP-1 Signaling and Muscle Metabolism GLP-1RAs modulate metabolism through multiple intracellular signaling pathways, including cAMP/PKA, PI3K/Akt, and SIRT1-mediated cascades, influencing glucose uptake, mitochondrial function, and inflammatory responses [82], which may contribute to interactions between GLP-1RA therapy and skeletal muscle metabolism, potentially affecting muscle metabolism and quality