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This anti-inflammatory role is further corroborated by evidence showing that APOM-S1P inhibits ox-LDL-induced inflammation in HUVECs via the S1PR2-mediated PI3K/Akt pathway[57] and that APOM/ mice exhibit significant increases in pro-inflammatory proteins like iNOS, NF-B, and IL-1 [58]

10.1038/nrm.2017.95 Nat

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