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Studies using beta-3 adrenergic receptor knockout mice confirmed the specificity of this mechanism, as these animals showed no fat loss response to AOD-9604

These duration and agent dependent associations are consistent with potential disease modifying activity beyond weight loss alone, although prospective trials are needed to establish causality and define optimal treatment targets." Commenting on the research, Professor Lucy Donaldson, director of research at Arthritis UK, described the study as "encouraging." She stated: "This is an encouraging study which suggests that people with knee osteoarthritis who were taking weight loss medications were less likely to need knee replacement surgery compared to those not taking these medicines