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Zinc-2-glycoprotein (ZAG) is a glycoprotein with a zinc-binding site that plays a pivotal role in lipid metabolism

Search and compare options Health experts are still studying exactly how metformin lowers vitamin B12 levels, but some of the main theories are: By causing changes in how calcium binds to vitamin B12 (calcium is required for certain parts of the intestine to absorb vitamin B12) By causing more vitamin B12 to be held by the liver, so less is available in rest of the body By lowering amount of intrinsic factor thats released in your stomach (intrinsic factor is a type of protein needed to absorb vitamin B12) By slowing the movement of food and increasing the amount of bacteria in the small intestine Its also good to note that metformin doesnt always cause vitamin B12 deficiency