Apart from the lack of proregenerative signaling, other factors such as cell cycle inhibition (eg, via p53/p21 pathways) and hepatocellular senescence in areas surrounding necrotic zones may have a significant role in the impairment of liver regeneration observed after severe APAP-induced liver injury
however, some discontinuations were actually due to "perceived excessive weight loss," highlighting the potency of the drug
Shearer J., Sellars E.A., Farah A., Graham T.E., Wasserman D.H
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