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However, Dihexa remains entirely preclinical, and its foundational research has faced serious integrity concerns including an expression of concern and a retraction on key papers

This publication introduced the concept of sequential batch correction: instead of treating a large data set all at once for batch correction, one can start with a subset of the data and correct only this, then add more and more batches sequentially for several correction rounds, allowing one to dynamically change normalization factors from round to round

They can lead to signs of premature aging and chronic diseases or conditions