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In obese mice, combining ERR activation with dietary control yields additive improvements in fat mass and hepatic features, suggesting compatibility with lifestyle or other pharmacological interventions

Common mistake: Increasing the dose because nothing is "felt." Community protocols hold at 300mcg for at least 4 weeks before considering adjustments

Increases in resting heart rate are a recognised class effect of incretin-based therapies and have been reported with GLP-1 receptor agonists more broadly, as reflected in the Summary of Product Characteristics (SmPC) for licensed agents such as semaglutide (Wegovy) and liraglutide (Saxenda)

Critically, AOD-9604 does NOT stimulate growth hormone receptor (GHR) signaling in the classical sense