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Receptor-independent effects of melatonin in CRC: Many of melatonins reported anticancer effects in CRC, including ROS modulation, regulation of MAPK/mTOR pathways, HDAC4 nuclear translocation, microRNA modulation, inhibition of NF-B and HIF-1 activity, and antioxidant enzyme activation, do not directly affect MT1/MT2 receptors and appear to be receptor-independent