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This culminated out of research led by Jens Holst (figure 26), who began his career in 1972 as a junior surgeon in the emergency ward and the department of gastric surgery at Bispebjerg Hospital in Copenhagen

(accessed on 25 September 2019)

12 Moreover, lipotoxicity, endotoxin translocation, and chronic low-grade inflammation activate Kupffer cells (KCs) and polarize immune cell populations, 13 contributing to a persistent pro-inflammatory hepatic microenvironment